The study was conducted on 70 cows of Friesian and Holstein breed in AL-Faihaa station, Babylon Governorate during the period from January 2002 to March 2002. The age of animals ranged between 2 to 7 years. The study was designed to know the prevalence of postpartum anestrus and their treatments in cows. The prevalence of postpartum anestrus was 51.42% (36/70). The animals suffering from persistent corpus luteum were showed an incidence of 38.88% (14/36). The animals were treated with 15 mg PGF2α i.m. The animals suffering from inactive ovaries were showed an incidence of 61.11% (22/36). The animals suffered from inactive ovaries (n = 22) were divided into three groups; the first group (n = 9) were treated with 50 ml Lugol’s Iodine solution 5% intra uterine; The second group (n = 6) were treated with 0.5 mg GnRH i.m. while the third group (n = 7) treated with 6 mg estradiol benzoate i.m. The efficiency of the treatments were 55.5% , 100% and 71.4% respectively. There was a significant difference (P< 0.05) between different groups. It was concluded from this study that the postpartum anestrus prevalence is high and could be treated with PGF2α or GnRH with high success rate.