The study was conducuted during 2004 season in Esehaki To find out the response of growth and yield soybean crop to nitrogen ,phosphorus and potassium Fertilizer in defferent levels. A randmized complete block design was used in afactorial experiment with three replication .The treatments included Tow cultivars (TN12 and DT84) with seven levels of NPK Fertilizer. The results showed that TN12 had higher yield of seed (1187.9) Kg/ ha. and nomber of pods per plant (33.3), No. of seed per pod (2.5) and higher plant height (65.1) cm. The treatment 140 kg N + 240 kg P2O5 + 75 kg K2O/ ha. was gaves higher yield (1309.2 Kg/ ha), (34.2) pods/ plant and (12.7) gram wieght of 100 seeds. A significant interaction between cultivars and Fertilizer levels was found. with treatment (T6) and cultivars (TN12 and DT84) produced higher yield and yield components.