The aim of this study was to evaluate the inhibition activity of extracts cortex against some types of food poisoning bacteria and yeast. The extracts were prepared with cold, hot water and Alchole with (25, 50, 75 and 100) % concentration. The experimental microorganism were Samonella typhimurium, Pseudomonas aeruginosa, Klebsiella spp. Bacillus subtilis, Clostridium spp., Staphylococcus aureus and Candida albicans. The result showed that Al-Chloe extract gave the best inhibition activity compared with other treatments and the best result were against Staphylococcus auras. The inhibition zone were 29 ml for 100% concentration. The inhibition activity for Al-Chole extract were compared with some antibiotics (Amoxicillin, Gentamycin, Tetracyclin and Vancomycin). The result showed that Al-Chole extract gave better inhibition activity compared with the antibiotics above.