Authors
1
Department of Animal Production, College of Agriculture, University of Anbar, Ramadi, Iraq
2
department of animal production, college of agriculture, university of anbar
,
Document Type : Research Paper
10.32649/ajas.2023.179767
Abstract
The study was conducted in the ruminant field of the Department of Animal Production/ College of Agriculture/ University of Anbar for the period from 10/24/2021 to 9/12/2021. The study aimed to know the effect of N-acetyl cysteine (NAC) supplement in synergy with selenium or zinc on the level of liver enzymes Aspartate Amino Transferase (AST), Alanine Amino Transferase (ALT), glutathione (GPX) and Malondialdehyde (MDA). 24 local ewes with an age of 3-5 years with a weight of 45-55 kg. Animals are divided into four treatments: The first group (T1) was treated with Group 2 (T2) (10 mg N-acytl cysteine/kg body weight + 0.03 mg selenium/kg body weight) and group III (T3) 10 mg N-acytl cysteine/ kg of body weight + 0.03 mg zinc/ kg of body weight) while the fourth treatment (T4) was left without treatment (control group). The results showed that there were no significant differences in the concentration level of ALT, AST with a significant superiority of GPX enzyme and a decrease in MDA within the treatments. In conclusion, the study that N-aceytl cysteine, selenium and zinc treatment did not affect the levels of liver enzymes with an improvement in the level of GPX enzyme and a decrease in MDA.
- Ademi, A., Bernhoft, A., Govasmark, E., Bytyqi, H., Sivertsen, T., and Singh, B. R. (2017). Selenium and other mineral concentrations in feed and sheep's blood in Kosovo. Translational Animal Science, 1(1): 97-107.
- Al-Alwani, M. I. M. (2022). Effect of dietary supplement dose N-acetylcysteine on some biochemical and microbial characteristics and reproductive performance of local ewes. MSc. Thesis, College of Agriculture, University of Al- Anbar.
- Alimohamady, R., Aliarabi, H., Bruckmaier, R. M., and Christensen, R. G. (2019). Effect of different sources of supplemental zinc on performance, nutrient digestibility, and antioxidant enzyme activities in lambs. Biological trace element research, 189: 75-84.
- Allawi, I. K. M. (2019). The Effect of Arginine, a mixture of selenium and vitamin E on the physiological and productive performance of pregnant Iraqi ewes. PhD Thesis, College of Agriculture, University of Al- Anbar.
- Arangasamy, A., Krishnaiah, M. V., Manohar, N., Selvaraju, S., Guvvala, P. R., Soren, N. M., ... and Ravindra, J. P. (2018). Advancement of puberty and enhancement of seminal characteristics by supplementation of trace minerals to bucks. Theriogenology, 110: 182-191.
- Aremmt, M. K. J. (2019). Effect of yeast (Saccharomyces Cerevisiae) enriched selenium or zinc in some physiological and reproductive traits of local sheep males. MSc. thesis, College of Agriculture, University of Anbar.
- Balani, Z. R. (2018). Effect of zinc and selenium on the some of productive and physiological traits of Karadi male sheep. PhD Thesis, College of Agriculture, University of Tikrit.
- Duncan, D. (1998). Multiple range and multiple F-tests. Biometrics 11, l-42. JMF Abreu, AM Bruno-Soares. Animal Feed Science Technology, 70: 49-57.
- Ebrahim, Z. K., Goma, A. A., and Lebda, M. A. (2016). Behavioral and biochemical alterations in sheep with trace elements deficiency: A trial for treatment. American Journal of Life Science Researches, 4(2).
- Faixová, Z., Piešová, E., Maková, Z., Čobanová, K., and Faix, Š. (2016). Effect of dietary supplementation with selenium-enriched yeast or sodium selenite on ruminal enzyme activities and blood chemistry in sheep. Acta Veterinaria Brno, 85(2): 185-194.
- Kakaei, F., Fasihi, M., Hashemzadeh, S., Zarrintan, S., Beheshtirouy, S., Asvadi-Kermani, T., Tarvirdizadeh, K., Rezaei, S., and Sanei, B. (2020). Effect of N-acetylcysteine on liver and kidney function tests after surgical bypass in obstructive jaundice: A randomized controlled trial. Asian Journal of Surgery, 43(1): 322-329.
- Kambe, T., Tsuji, T., Hashimoto, A., and Itsumura, N. (2015). The physiological, biochemical, and molecular roles of zinc transporters in zinc homeostasis and metabolism. Physiological Reviews, 95(3): 749-784.
- Lai, Q., Xiang, W., Li, Q., Zhang, H., Li, Y., Zhu, G., Xiong, C., and Jin, L. (2018). Oxidative stress in granulosa cells contributes to poor oocyte quality and IVF-ET outcomes in women with polycystic ovary syndrome. Frontiers of Medicine, 12(5): 518-524.
- Manes, J., Ríos, G., Fiorentino, M. A., and Ungerfeld, R. (2016). Vaginal mucus from ewes treated with progestogen sponges affects quality of ram spermatozoa. Theriogenology, 85(5): 856- 861.
- Mansoor, A. R., Saleh, I. D., Dakheel, H. A., and Quarter, H. (2020). Effect of addition of melatonin to the intravaginal sponges on oxidative status and reproductive performance in Iraqi awassi ewes. Annals of Tropical Medicine and Public Health, 23: 120-127.
- Mohammad, M. K., Zhou, Z., Cave, M., Barve, A., and McClain, C. J. (2012). Zinc and liver disease. Nutrition in Clinical Practice, 27(1): 8-20.
- Rakshith, Sh., Nayanabhirama, U., Srinivas, M., Vijay, K., and Vinay, R. (2019). Mechanisms and Therapeutics of N-acetylcysteine: A Recent Update. Research Journal of Pharmacy and Technology, 12(5): 2584-2588.
- Ross, A. C., Caballero, B. H., Cousins, R. J., Tucker, K. L., and Ziegler, T. R. (2012). Modern nutrition in health and disease. 11th ed. Wolters Kluwer Health Adis (ESP). 225-237.
- (2012). Statistical Analysis System, User's Guide. Statistical. Version 9.6th ed. SAS. Inst. Inc. Cary. N.C. USA.
- Singh, B., Natesan, S. K. A., Singh, B. K., and Usha, K. (2005). Improving zinc efficiency of cereals under zinc deficiency. Current Science, 88(1): 36-44.
- Snider, A. P., and Wood, J. R. (2019). Obesity induces ovarian inflammation and reduces oocyte quality. Reproduction, 158(3): 79-90.
- Solaiman, S. G., Shoemaker, C. E., and D’andrea, G. H. (2006). The effect of high dietary Cu on health, growth performance, and Cu status in young goats. Small Ruminant Research, 66(1-3): 85-91.
- Swain, P. S., Rao, S. B., Rajendran, D., Dominic, G., and Selvaraju, S. (2016). Nano zinc, an alternative to conventional zinc as animal feed supplement: A review. Animal Nutrition, 2(3): 134-141.